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Comparison of anidulafungin's and fluconazole's in vivo activity in neutropenic and non-neutropenic

Lethal human neutropenic entercolitis caused by Clostridium chauvoei in the United States: Tip of th

Management of neutropenic enterocolitis in children with cancer

Efficacy and safety of micafungin as an empirical antifungal therapy for suspected fungal infection

Pharmacodynamics of TD-1792, a Novel Glycopeptide-Cephalosporin Heterodimer Antibiotic Used against

Clinical features and outcomes of Staphylococcus aureus infections in non-neutropenic cancer patient

Analysis of leukopenia and anemia after gastric bypass surgery

Clozapine-induced late leukopenia

Bacteraemia due to Eikenella corrodens secondary to periodontal infection in a neutropenic patient

Successful treatment of NDM-1 Klebsiella pneumoniae bacteraemia in a neutropenic patient

The shape of the myelosuppression time profile is related to the probability of developing neutropen

Rectal Involvement in Neutropenic Enterocolitis

Why is My Patient Neutropenic?

Cost-effectiveness of posaconazole versus fluconazole or itraconazole in the prevention of invasive

Prospective study in critically ill non-neutropenic patients: diagnostic potential of (1,3)-beta-D-g

Preterm neonates show marked leukopenia and lymphopenia that are associated with increased regulator

Diagnostic yield of bronchoscopic sampling in febrile neutropenic patients with pulmonary infiltrate

Antibody specific to thioredoxin reductase as a new biomarker for serodiagnosis of invasive aspergil

Comparative Effectiveness of Filgrastim, Pegfilgrastim, and Sargramostim as Prophylaxis Against Hosp

Demographics, morbidity, and mortality febrile neutropenic adult patients treated with cefepime

应用抗甲状腺药物致粒细胞缺乏患者感染的临床研究
作 者:任蕾,秦贵军,郑丽丽,张会娟,孙良阁,段宇

中华医院感染学杂志 2014年第24卷第17期

【摘要】目的 分析使用抗甲状腺药物(ATD)引起粒细胞缺乏及引发感染患者的临床特点和感染部位、病原菌分布及其耐药性。 方法 回顾性分析72例使用ATD引起粒细胞缺乏及引发感染患者的临床资料,采用SPSS11.0 软件进行统计分析。 结果 72例患者感染部位以呼吸道为主,占55.3%,其次为泌尿系、胃肠道,分别占21.1% 和10.5%;共分离出病原菌52株,其中革兰阳性菌20株占38.5%;革兰阴性菌26株占50.0%;真菌6株占 11.5%;革兰阳性菌对万古霉素和替考拉宁敏感性最高,分别为90.0%和100.0%,对其他抗菌药物均存在不同 程度的耐药性;革兰阴性菌对美罗培南和亚胺培南敏感性最高,均为92.3%,对第三代头孢类药物、阿米卡星等 存在不同程度的耐药性。结论!使用 ATD容易引起患者粒细胞缺乏,继而诱发各种感染,且感染部位以呼吸道 最为常见,引起感染的病菌中革兰阴性菌与革兰阳性菌相当,真菌感染相对较少。

【关键词】抗甲状腺药物;粒细胞缺乏;感染