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Development of Novel PCR Assays To Detect Azole Resistance-Mediating Mutations of the Aspergillus fu

Pulmonary Zygomycosis in a Non-neutropenic Patient With Myelodysplastic Syndrome on Lenalidomide

Prognosis of acute respiratory distress syndrome in neutropenic cancer patients

Early ultrasonographic finding of septic thrombophlebitis is the main indicator of central venous ca

Systematic review and meta-analysis of the value of clinical features to exclude radiographic pneumo

Pharmacokinetics of Tulathromycin in Healthy and Neutropenic Mice Challenged Intranasally with Lipop

Effects of cepharanthine with or without Z-100 against leukopenia during radiation therapy for oral

Questioning the Role of a Neutropenic Diet following Hematopoetic Stem Cell Transplantation

A European survey relating to cancer therapy and neutropenic infections: Nurse and patient viewpoint

Multiple cutaneous neutropenic ulcers associated with azathioprine

Diagnostic value of routine chest radiography in febrile, neutropenic children for early detection o

Pandemic 2009 influenza A(H1N1) virus infection coinciding with invasive pulmonary aspergillosis in

Comparative Pharmacodynamics of the New Oxazolidinone Tedizolid Phosphate and Linezolid in a Neutrop

Sudden Atelectasis and Respiratory Failure in a Neutropenic Patient: Atypical Presentation of Pseudo

ESCMID* guideline for the diagnosis and management of Candida diseases 2012: non-neutropenic adult p

Can procalcitonin distinguish infectious fever from tumor-related fever in non-neutropenic cancer pa

Nasopharyngeal Detection of Respiratory Viruses in Febrile Neutropenic Children

Clinical utility and prognostic value of galactomannan in neutropenic patients with invasive aspergi

Diet of neutropenic patients in pediatric oncology service; the experience of the university hospita

Major surgery in a neutropenic patient undergoing allogeneic stem cell transplantation for high risk

应用抗甲状腺药物致粒细胞缺乏患者感染的临床研究
作 者:任蕾,秦贵军,郑丽丽,张会娟,孙良阁,段宇

中华医院感染学杂志 2014年第24卷第17期

【摘要】目的 分析使用抗甲状腺药物(ATD)引起粒细胞缺乏及引发感染患者的临床特点和感染部位、病原菌分布及其耐药性。 方法 回顾性分析72例使用ATD引起粒细胞缺乏及引发感染患者的临床资料,采用SPSS11.0 软件进行统计分析。 结果 72例患者感染部位以呼吸道为主,占55.3%,其次为泌尿系、胃肠道,分别占21.1% 和10.5%;共分离出病原菌52株,其中革兰阳性菌20株占38.5%;革兰阴性菌26株占50.0%;真菌6株占 11.5%;革兰阳性菌对万古霉素和替考拉宁敏感性最高,分别为90.0%和100.0%,对其他抗菌药物均存在不同 程度的耐药性;革兰阴性菌对美罗培南和亚胺培南敏感性最高,均为92.3%,对第三代头孢类药物、阿米卡星等 存在不同程度的耐药性。结论!使用 ATD容易引起患者粒细胞缺乏,继而诱发各种感染,且感染部位以呼吸道 最为常见,引起感染的病菌中革兰阴性菌与革兰阳性菌相当,真菌感染相对较少。

【关键词】抗甲状腺药物;粒细胞缺乏;感染